# Methods for Selective Organic Synthesis based on Ionic Catalysts

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA BERKELEY · 2021 · $20,958

## Abstract

Methods for Selective Organic Synthesis based on Ionic Catalysts
Project Summary
The major goal of this research program is to develop catalytic enantioselective transformations based on
transition metal and chiral anion catalysis that will be broadly applicable to the preparation of therapeutically
relevant organic molecules. Towards this end, new enantioselective reactions of carbon-carbon π-bonds are
proposed, with a major emphasis placed on the development of enantioselective sp3-C-F bond construction.
Additionally, reactions that generate or employ available building blocks, such as alkenes and boronic acids, will
be targeted. These methods will be exploited in the enantioselective construction of fluorinated building blocks,
heterocycles and natural product analogs. Thus, we anticipate that the proposed air and moisture tolerant
transformations will provide synthetic chemists and biomedical researchers with additional tools for molecular
synthesis and for single enantiomer construction.

## Key facts

- **NIH application ID:** 10386162
- **Project number:** 3R35GM118190-06S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** F. Dean Toste
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $20,958
- **Award type:** 3
- **Project period:** 2016-06-03 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10386162

## Citation

> US National Institutes of Health, RePORTER application 10386162, Methods for Selective Organic Synthesis based on Ionic Catalysts (3R35GM118190-06S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10386162. Licensed CC0.

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