# Determinants of obesity-associated insulin resistance

> **NIH NIH K23** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2021 · $42,625

## Abstract

This extension request describes a 4-month funded extension for the K23 awardee who is in her final
year of funding (5K23HL135394-05). The recipient experienced an 8-month research interruption due to
lab closures and clinical research restrictions on Boston University Medical Campus due to the COVID-
19 pandemic. Further COVID-19 disruptions extended this research interruption by an additional 19-
weeks. However, with the current COVID-19 situation improving in the Boston area, the applicant’s
research program is operating at maximum capacity and will generate sound scientific data for the
outcomes in Aims 1 and 2 within the original funding period. The 4-month funded extension is essential
for this early stage investigator to develop more complete and scientifically robust answers to the
outcomes proposed in Aim 3 that are currently trending toward significance. Briefly, Aim 3 examines the
effect of surgical weight loss on insulin resistance, micro- and macrovascular functions, fat tissue
histopathology and adipose tissue characteristics by CT imaging. During the 8-month COVID-19 shut
down, 35% of the enrolled participants became ineligible for their 6-month post bariatric surgical return
visit. Thus, the combination of her current recruiting efforts and the additional 4-months extension of
salary support will not only provide time but the resources to complete the studies that are likely to
provide novel and clinically important information regarding mechanisms of obesity-related vascular
disease in severely obese individuals.

## Key facts

- **NIH application ID:** 10386286
- **Project number:** 3K23HL135394-05S1
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** Melissa G Farb
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $42,625
- **Award type:** 3
- **Project period:** 2017-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10386286

## Citation

> US National Institutes of Health, RePORTER application 10386286, Determinants of obesity-associated insulin resistance (3K23HL135394-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10386286. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*