# NIH ADMINISTRATIVE SUPPLEMENT AUTOMATED PEPTIDE SYNTHESIZER ZHUANG

> **NIH NIH R01** · UNIVERSITY OF DELAWARE · 2021 · $69,738

## Abstract

ABSTRACT
This supplement is requested to support R01 GM129468: Decoding the non-canonical
polyubiquitin chains using chemical approaches. The goal of the parent proposal is to develop
new approaches for protein polyubiquitination and subsequent identification and characterization
of readers of the noncanonical ubiquitin chains in DNA damage tolerance. The success of this
proposal critically depends on the ability to generate modified ubiquitin species that contain
reactive linker molecules or unnatural amino acids. Using automated solid-phase peptide
synthesis (SPPS) to generate the critical ubiquitin species in sufficiently large quantity will ensure
the success of proposed research.

## Key facts

- **NIH application ID:** 10387411
- **Project number:** 3R01GM129468-03S1
- **Recipient organization:** UNIVERSITY OF DELAWARE
- **Principal Investigator:** Zhihao Zhuang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $69,738
- **Award type:** 3
- **Project period:** 2019-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10387411

## Citation

> US National Institutes of Health, RePORTER application 10387411, NIH ADMINISTRATIVE SUPPLEMENT AUTOMATED PEPTIDE SYNTHESIZER ZHUANG (3R01GM129468-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10387411. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*