# The BMRB as an evolving resource for biomolecular structure-function research

> **NIH NIH R01** · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2021 · $180,746

## Abstract

The Biological Magnetic Resonance Data Bank (BMRB) is the international open repository for
biomolecular NMR data. BMRB hosts tens of thousands of curated chemical shifts, coupling
constants, relaxation rates, and other NMR parameters for proteins, nucleic acids, and small
molecules (including metabolites). The data in BMRB has led to advances in protein structure
determination, functional annotation of proteins of unknown function, and the analysis of the
spectra of biofluids and other complex mixtures. A highly-utilized service of BMRB is a portal,
backed by high performance computational resources, is the computation of protein structures
from chemical shifts using the CS-Rosetta software. As a result of the move of BMRB from the
University of Wisconsin to UConn Health, BMRB lost access to computational resources at UW.
We propose to acquire a computational cluster to continue support of the CS-Rosetta service.

## Key facts

- **NIH application ID:** 10387674
- **Project number:** 3R01GM109046-08S1
- **Recipient organization:** UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- **Principal Investigator:** JEFFREY C HOCH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $180,746
- **Award type:** 3
- **Project period:** 2014-05-15 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10387674

## Citation

> US National Institutes of Health, RePORTER application 10387674, The BMRB as an evolving resource for biomolecular structure-function research (3R01GM109046-08S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10387674. Licensed CC0.

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