# Strategies and Methods for Complex Molecule Synthesis

> **NIH NIH R35** · UNIVERSITY OF CALIFORNIA BERKELEY · 2021 · $69,961

## Abstract

Summary of Current MIRA Award (R35GM130345)
The goal of this program is to develop new strategies and methods for the synthesis of
biologically active secondary metabolites (natural products). A significant portion of our
efforts is dedicated to identifying efficient preparations of compounds, which, along with
their unique derivatives, will serve as novel small molecules to combat a range of
indications associated with cancer, inflammation, and pain. Our synthetic studies are
focused on C–C bond cleavage methodology, novel enantioselective halogenation and
cycloaddition reactions, as well other methods for molecular editing. Our current work
also highlights new directions for the use of carvone and pyrone as a sustainable
starting material for enantioselective and enantiospecific syntheses. Finally, through
collaborations, we will gain unique entry into the use of natural products and their
derivatives to perturb biological function and ultimately provide promising starting points
for new therapeutics.

## Key facts

- **NIH application ID:** 10387754
- **Project number:** 3R35GM130345-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Richmond Sarpong
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $69,961
- **Award type:** 3
- **Project period:** 2019-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10387754

## Citation

> US National Institutes of Health, RePORTER application 10387754, Strategies and Methods for Complex Molecule Synthesis (3R35GM130345-03S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10387754. Licensed CC0.

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