# Systems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia

> **NIH NIH R01** · JACKSON LABORATORY · 2022 · $887,525

## Abstract

PROJECT SUMMARY
Our proposed research is expected to identify genetic factors that underlie disordered sleep associated with
Alzheimer's disease (AD), and determine if they are intervenable to stave off cognitive symptoms. Detection
and validation of these genes will promote possible treatments through discovery of new targets and biological
pathways that may aid in alleviating disease burden and improving quality of life in humans. The data
generated in this proposal will also be cross-checked with available datasets from human cohorts and
postmortem samples, such that advances in our current understanding of the networks and mechanisms in
mice can be understood in the context of human AD. We will leverage advanced mouse models to
identify
molecular and cellular mechanisms underlying the bidirectional relationship between AD pathology and
disruptions in sleep. In Aim 1, we will identify genes and molecular networks associated with sleep loss in a
large population of AD mice that better model human AD. In Aim 2, we will translate genes and networks
underlying variation in sleep loss to human AD cohorts. Finally, in Aim 3, we will validate genetic and
modifiable factors associated with sleep loss and dysfunction, and determine their effects on onset and
progression of memory deficits in powerful AD models.

## Key facts

- **NIH application ID:** 10388971
- **Project number:** 1R01AG076129-01
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** CATHERINE COOK KACZOROWSKI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $887,525
- **Award type:** 1
- **Project period:** 2022-02-01 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10388971

## Citation

> US National Institutes of Health, RePORTER application 10388971, Systems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia (1R01AG076129-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10388971. Licensed CC0.

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