# Role of Structural Remodeling in Atrial Fibrillation

> **NIH NIH F31** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2022 · $35,878

## Abstract

7. Project Summary
Current treatments for persistent atrial fibrillation (AF) are associated with high recurrence rates due to our limited
understanding of how AF develops and sustains. In patients with AF, structural remodeling in the form of fibrosis
is often present, indicating that structural remodeling may have a role in AF development. This project aims to
identify the role of fibrosis in AF by using a transgenic goat model. In aim 1, we strive to show the importance of
structural remodeling compared to electrical remodeling in AF developing. In aim 2, the architecture of structural
remodeling will be investigated to identify if differences in the underlying fibrotic architecture lead to increased
AF susceptibility. In aim 3, the fibrotic architecture will be compared to in-vivo electrical mapping data to
determine how varying degrees of fibrosis affect conduction patterns. The results of this project will investigate
if there is a causal relationship between structural remodeling and impaired conduction. Success in this project
will lead to improved ablation targets for patients with persistent AF, leading to lower recurrence rates.
Completing this project provides valuable scientific and technical training to develop into an independent
researcher.

## Key facts

- **NIH application ID:** 10389280
- **Project number:** 1F31HL162527-01
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Eugene Kwan
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $35,878
- **Award type:** 1
- **Project period:** 2022-01-01 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10389280

## Citation

> US National Institutes of Health, RePORTER application 10389280, Role of Structural Remodeling in Atrial Fibrillation (1F31HL162527-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10389280. Licensed CC0.

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