# Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease

> **NIH NIH RF1** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $169,879

## Abstract

PROJECT SUMMARY /ABSTRACT (from the Parent Grant)
There is considerable individual variability in how much and how quickly cognitive abilities change with age.
The better we understand the biological mechanisms that influences if and how aging affects brain structure
and function, the more able we will be to intervene effectively in a person-specific manner. The overarching
goal of this renewal application is to better understand the inflammatory, vascular, neurodegenerative, and
lifestyle/behavioral contributions to this clinically important diversity in brain aging trajectories. We propose to
continue following our deeply phenotyped cohort of 250 functionally intact older normals with our detailed
cognitive, neuroimaging, and biometric characterizing over two additional time points. Our first aim is to define
the separate and interactive pathways by which biologic and lifestyle variables influence age-related decline in
brain structure and function Our second aim will determine of predictive value of innovative plasma markers of
proteins associated with Alzheimer’s and neurodegeneration. Our third aim will incorporate innovative,
objective, real-time measures of sleep and physical activity. Accomplishing these aims will have a highly
significant impact on the field. Validating plasma biomarkers of pathology and clarifying the complex interplay
of factors that influence brain aging trajectories will lead to better prediction and prevention of adverse brain
aging and inform person-specific interventions.

## Key facts

- **NIH application ID:** 10390159
- **Project number:** 3RF1AG032289-11S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** JOEL H KRAMER
- **Activity code:** RF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $169,879
- **Award type:** 3
- **Project period:** 2009-06-15 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10390159

## Citation

> US National Institutes of Health, RePORTER application 10390159, Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative Disease (3RF1AG032289-11S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10390159. Licensed CC0.

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