# Einstein Aging Study

> **NIH NIH P01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2021 · $660,876

## Abstract

Abstract
The Einstein Aging Study (EAS) has long focused on the risk factors and cognitive changes that predict the
subsequent onset of dementia, particularly Alzheimer’s dementia and related dementias (ADRD). The study is
based on a community based cohort of older adults from Bronx County, NY. In the current funding period, we
have developed novel intensive longitudinal methods to assess cognitive status and risk factors for ADRD
using ecological momentary assessment (EMA) methods. These improve upon some limitations of single-shot
clinic based assessments, providing measures of cognitive function in everyday life, enabling analyses of
within person variability in cognitive function, and capturing data on exposures in “real-time” versus
retrospective recall. The novel ambulatory measures are combined with robust clinic-based measures of
cognitive performance, biomarkers, health status and health behaviors to identify early cognitive changes and
decline and modifiable risk factors in the pre-clinical phase of ADRD.
We have recently submitted a renewal P01 application for the EAS in response to the funding opportunity
PAR- 19-314 (January 25, 2021) that will extend this work by utilizing mobile devices to capture the dynamic
time-varying nature of risk factors and cognitive performance as participants engage in their usual daily
activities in order to elucidate pathways linking behavioral, social/emotional and metabolic health, as well as
environmental factors to early cognitive decline. Capitalizing on the increasing diversity of the EAS community,
the project includes emphasis on examining social factors related to racial/ethnic disparities in cognitive health.
In order to accomplish the P01s goals, it is important to keep intact the EAS established infrastructure
(including valued staff who connect with participants and help with retention), continue the comprehensive
characterization of the existing cohort, avoid gaps in ascertainment of outcomes and time varying exposures,
maintain data quality, continue existing collaborations and obtain brains and perform autopsies for EAS
participants in the ”Gift of Autopsy” program.
The EAS has made significant contributions to cognitive aging research. Above and beyond contributions
linked to project aims, the diverse, community-based cohort is recognized as a valuable resource that is used
in numerous national and international collaborative projects. In this supplement, we request bridge funding
to maintain high retention of the existing racially/ethnically diverse cohort and maintain the critically
established infrastructure while the renewal application is under consideration. The current EAS funding
period ends on May 31, 2021. If funded based on the January 25th submission, the start date would not begin
until December 1, 2021. If necessary, the resubmission date in response to PAR- 19-314 would be in
September, 2021, with a start date of June 1, 2021.

## Key facts

- **NIH application ID:** 10391027
- **Project number:** 3P01AG003949-37S2
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Richard B. LIPTON
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $660,876
- **Award type:** 3
- **Project period:** 2021-06-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10391027

## Citation

> US National Institutes of Health, RePORTER application 10391027, Einstein Aging Study (3P01AG003949-37S2). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10391027. Licensed CC0.

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