PROJECT SUMMARY Since its inception in 1980, the International Vascular Biology Meeting (IVBM) has been a time-honored and profoundly impactful biennial event. This meeting provides a unique opportunity for the global community to exchange and discuss new scientific discoveries, and to chart innovative and collaborative future scientific directions in vascular biology. The IVBM has also served to foster the next generation of scientists in vascular medicine. IVBM 2022 (October 13-17, 2022 in Oakland, CA) will cover a broad spectrum of vascular biology, prioritizing emerging areas of research. The vasculature impacts every organ system in development, aging, and disease and is critical to processes of regeneration. Blood vessel walls regulate multiple physiological functions, including vasomotor tone, leukocyte trafficking, innate and acquired immunity, permeability, stem cell differentiation, regeneration, and new blood formation. Abnormalities in any of these functions lead to disease. Beyond traditional vessel wall pathologies such as atherosclerosis and hypertension, the vasculature contributes to cancer, neurological disease, diabetes, hematological and immunological disorders, aging, and infectious processes, most recently COVID-19. Mounting evidence suggests that many COVID-19 symptoms are due to the virus attacking the vasculature. Advances in vascular biology have led to the development of many new therapies and preventive strategies with broad impact including those mitigating tumor growth and restoring vision. IVBM 2022 will provide a timely forum to exchange new knowledge in the rapidly expanding field of vascular biology, facilitate cross-disciplinary collaboration and critical interactions between seasoned investigators and trainees, and promote awareness of diverse vascular beds in health and disease. Our objective is to ignite novel areas of research between academia and industry, and from basic to translational research and clinical medicine, with the ultimate goal of improving human health. IVBM 2022 is being organized by the North American Vascular Biology Organization (NAVBO), an organization with a strong track record of promoting trainees and junior faculty. A significant number of oral presentations are reserved for junior scientists to promote their career growth. NAVBO is committed to diversity and equity within and beyond the vascular biology community; the IVBM organizers and speakers include women, junior faculty, underrepresented groups, and scientists from around the world. We selected the diverse city of Oakland, CA as the conference site. Our program facilitates cross-fertilization of scientific insights related to different vascular beds (brain, heart, lung, kidney, liver, and eye) and diverse disciplines (cell biology, genetics, imaging, bioengineering, mathematics, physics, systems biology, translational research, and drug discovery). By promoting such interactions, we will generate new basic knowledge of develop...