# Mechanisms & risk factors of chronic lung disease in HIV+ adolescents in Nairobi

> **NIH NIH K23** · UNIVERSITY OF WASHINGTON · 2021 · $66,960

## Abstract

PROJECT SUMMARY/ABSTRACT
Candidate: Dr. Attia’s long-term goal is to improve lung health globally, conducting clinical research and trials
in chronic lung diseases, with a focus on the role of HIV and other risk factors in influencing the pathophysiology
and clinical course of lung disease. Research proposed in this funded extension of her K23 Career Development
Award builds on her previous and ongoing work, which demonstrates a substantial burden of chronic lung
disease among adolescents living with HIV in a resource-limited setting. This extension will provide Dr. Attia
with essential protected time to complete longitudinal analyses for Aim 2 and 3 of her K23 research, submit
R01 applications, and continue training to support her goal of becoming an independent investigator at the
intersection of pulmonary disease, HIV and global health. During the extension, Dr. Attia will continue to solidify
her expertise in: 1) training in analysis of lung growth in adolescents; 2) advanced biostatistical methods to
analyze complex correlated and missing data. These objectives will be achieved through a career development
plan that incorporates coursework and continued mentoring by an advisory committee with expertise in lung
disease and lung growth, HIV, epidemiology, biostatistics, and the use of biospecimens in clinical research.
Environment: The rich academic environment at the University of Washington (UW) is an ideal place for Dr.
Attia’s continued research training. UW is an outstanding biomedical research institution with a strong
commitment to promoting the academic careers of promising investigators. The UW Division of Pulmonary and
Critical Care Medicine is widely recognized for its Clinical Research Training Track and offers an intellectual
environment that supports development of the skills necessary to achieve academic success. As co-director of
the UW Department of Global Health Teaching, Research and Expert Education program, Dr. Attia will have
full access to resources that support the administrative, clinical, laboratory and database management
infrastructure for clinical research at the UW-affiliated Coptic Hope Center for Infectious Diseases in Nairobi,
Kenya. She will also have access to biostatistical support through the UW CTSA and School of Public Health.
Research: During this extension, Dr. Attia will examine differences in subtypes, risk factors and mechanisms
of chronic lung disease, based on repeat pre- and post-bronchodilator spirometry obtained over 3-4 years in
161 adolescents living with HIV from the Hope Center compared to 174 HIV-uninfected adolescents. She will:
1) determine the role of HIV on change in lung function over time, considering the complex interplay with other
risk factors including malnutrition and indoor biofuel burning; 2) evaluate whether HIV severity, and biomarkers
of immune activation and inflammation are associated with diminished lung function growth over time. Findings
will provide novel insights into...

## Key facts

- **NIH application ID:** 10392286
- **Project number:** 3K23HL129888-05S2
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Engi Farouk Attia
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $66,960
- **Award type:** 3
- **Project period:** 2021-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10392286

## Citation

> US National Institutes of Health, RePORTER application 10392286, Mechanisms & risk factors of chronic lung disease in HIV+ adolescents in Nairobi (3K23HL129888-05S2). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10392286. Licensed CC0.

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