# SF Bay Area MACS/WIHS Combined Cohort Study

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $44,725

## Abstract

This study complements the important ongoing MWCCS-wide COVID-19 study of vaccine
hesitancy, compliance and uptake. Our mixed-methods approach (Aim 1) will leverage MWCCS
core collection of vaccine uptake in order to establish temporal pathways and nuanced
relationships between social position, medical mistrust, vaccine benefit mistrust, concerns about
side effects, worries about corporate vaccine profiteering, and the preference for natural
immunity. We will also build on existing core collection of general vaccine acceptance by 1)
developing a new instrument assessing awareness of vaccine eligibility and access; 2)
incorporating a vaccine communication instrument to better target messaging to high-risk
populations; and 3) integrate a micronarrative component to explore in greater nuance
individual-level factors that influence vaccine uptake decision-making, perceptions of vaccine
communication strategies, vaccine distribution, and perceived vaccine hesitancy behaviors of
the household and community. In addition, the data we propose to collect in the supplement
could be leveraged after integration with COVID-19 core survey behavioral data to assess post-
vaccine changes to COVID-19 prevention behaviors. This study will offer important insight into
COVID-19 vaccine hesitancy and obstacles to vaccine acceptance, in addition to informing
targeted communication strategies and intervention efforts that improve trust, increase uptake
and break COVID-19 transmission dynamics among high-risk, aging populations with high
comorbidity burden, exemplified in the MWCCS cohort.

## Key facts

- **NIH application ID:** 10392771
- **Project number:** 3U01HL146242-03S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Bradley E Aouizerat
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $44,725
- **Award type:** 3
- **Project period:** 2019-04-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10392771

## Citation

> US National Institutes of Health, RePORTER application 10392771, SF Bay Area MACS/WIHS Combined Cohort Study (3U01HL146242-03S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10392771. Licensed CC0.

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