# Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

> **NIH NIH T32** · UNIVERSITY OF TEXAS MED BR GALVESTON · 2022 · $341,435

## Abstract

Project Summary/Abstract
We proposed creating a highly collaborative pre- and post-doctoral training program in the pathophysiology of
Alzheimer’s disease and other related neoconservative disorders. Our program is dedicated on advancing pre-
and post-doctoral fellows into independent research scientists at research intensive universities and health-
related research laboratories. Our trainees will be mentored by members of the Mitchell Center for
Neurodegenerative Diseases at the University of Texas Medical Branch – Galveston. Our highly collaborative
faculty reach across multiple departments allowing them to employ a number of experimental approaches to the
problems associated with Alzheimer's disease. Our training program incorporates cellular animal models,
disease progression mechanisms and pharmacological manipulations, immunotherapeutic approaches targeting
tau and amyloid oligomers, synaptic electrophysiology and, DNA damage and repair in neurodegeneration,
genetics of synaptic development and degeneration, molecular mechanisms in cognitive resilience, and
metabolic determinants of neurodegeneration. A strength of our training program is the investment UTMB has
made in developing this highly collaborative team as demonstrated by our joint publications and funded grants.
Our four pre-and three post-doctoral trainees will be closely mentored throughout their training. Our pre-doctoral
trainees will be required to take several new courses devoted to the cellular signaling in neurodegeneration and
the biochemistry and biophysics of amyloid proteins, while our post-doctoral trainees will participate in a
certificate program in advanced biomedical research strategies. All trainees will participate in seminars,
community building events, journal clubs and active collaborative research training. We have proposed a
framework that will enable us to train and mentor both pre- and post-doctoral trainees on their way to becoming
independent scientist to help address the Alzheimer’s medical needs of the country.

## Key facts

- **NIH application ID:** 10394187
- **Project number:** 5T32AG067952-02
- **Recipient organization:** UNIVERSITY OF TEXAS MED BR GALVESTON
- **Principal Investigator:** Rakez Kayed
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $341,435
- **Award type:** 5
- **Project period:** 2021-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10394187

## Citation

> US National Institutes of Health, RePORTER application 10394187, Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology (5T32AG067952-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10394187. Licensed CC0.

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