# EMRSHN: Exploring the Modulatory Role of Sec Hormones Along the Neuromechanical Axis in Females

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $56,306

## Abstract

Project Summary
Building off of our current R01, we propose to characterize the effect of systemic hormone
concentrations on basic skeletal muscle characteristics. Initially, young and otherwise healthy
female surgical patients will be recruited to determine an associative mapping between muscle
fiber composition and E2 concentration using histology and protein/gene expression of skeletal
muscle biopsies. Next, young and healthy female subjects would be recruited to identify potential
muscle fiber composition changes over a limited time window during the menstrual cycle, using a
state-of-the-art 7 Tesla scanner to perform magnetic resonance spectroscopy. Finally, young and
healthy female subjects would be recruited to identify the potential effect of the endocrinological
state on muscle plasticity by monitoring circulating myomiRs and muscle activity during exercise.
If successfully completed, these aims would reveal a relationship between a subject’s
endocrinological state and acute changes in basic muscle phenotype and the associated changes
in neuromuscular control. Taken together these aims have the potential to elucidate the
underlying biological mechanisms that may drive the sex-disparity seen in musculoskeletal injury
and to guide future research in injury prevention strategies.

## Key facts

- **NIH application ID:** 10394668
- **Project number:** 3R01AR069176-04S1
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** Yasin Yousef Dhaher
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $56,306
- **Award type:** 3
- **Project period:** 2016-09-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10394668

## Citation

> US National Institutes of Health, RePORTER application 10394668, EMRSHN: Exploring the Modulatory Role of Sec Hormones Along the Neuromechanical Axis in Females (3R01AR069176-04S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10394668. Licensed CC0.

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