# Vermont Center for Immunobiology/Infectious Diseases (VCIID)

> **NIH NIH P30** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2021 · $308,903

## Abstract

Abstract: scope of parent award and relevance to the NOSI on women's health
 The parent award, P30 GM118228, COBRE Phase III, supports the Vermont Center for Immunology and
Infectious Diseases (VCIID) at the University of Vermont (UVM). The VCIID represents a multidisciplinary group
of scientists and clinicians undertaking collaborative research in basic immunology, autoimmunity, microbial
pathogenesis, and host response to infections. The keystone of the VCIID is scientific excellence through
dedicated mentoring of talented junior faculty in an atmosphere that is both engaging and rigorous. In Phase III
we seek to coalesce our mutual interests along research lines that will maintain our competitiveness and
encourage basic, translational, and entrepreneurial research projects. We will foster this effort through the
support of Pilot Project and Core Facilities, and administrative support.
 This Supplement Application represents a collaboration between two VCIID faculty members who are basic
researchers, and two physician-scientists in the department of Department of Obstetrics, Gynecology and
Reproductive Sciences. On both sides, there is a junior investigator paired with a senior investigator
(respectively: Dr. Krementsov and Dr. Teuscher from VCIID; Dr. Brodeur and Dr. McGee from Ob-Gyn), which
fits with VCIID's goal of support for junior faculty, as well as cross-departmental and interdisciplinary
collaboration. The scientific goals of this Supplement Application are to investigate the mechanisms regulating
innate immune cell functionality in the context of autoimmune disease and normal reproductive function. As such,
this fits well within the scope of the VCIID, which supports basic immunology and autoimmunity research.
 With regard to relevance to women's health, in this supplement application, we propose a basic science
approach to dissect molecular mechanisms whereby female reproductive hormones regulate immune cell
function in the context of: 1) an autoimmune disease (MS, with highly biased incidence in females), and 2) female
reproductive organ function. The NOSI states that the “proposed research must address at least one of the
strategic goals of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research”. Our proposed
research will address Strategic Objectives 1.1 (basic biology of sex differences), 1.2 (influence of sex on
disease), and 1.5 (research on female reproductive function).

## Key facts

- **NIH application ID:** 10395160
- **Project number:** 3P30GM118228-05S3
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Ralph C Budd
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $308,903
- **Award type:** 3
- **Project period:** 2020-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10395160

## Citation

> US National Institutes of Health, RePORTER application 10395160, Vermont Center for Immunobiology/Infectious Diseases (VCIID) (3P30GM118228-05S3). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10395160. Licensed CC0.

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