# New Mexico Center for Metals in Biology and Medicine - Equipment Supplement

> **NIH NIH P20** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2021 · $250,000

## Abstract

Administrative Suppl. for Equipment Purchases for NIGMS-funded Center and Core Facilities NOT-GM-21-029
Summary Inorganic metals have long been a focus of biomedical research in New Mexico, due to the high
prevalence of mining-related metal contaminants in the region. At the University of New Mexico Center for
Metals in Biology and Medicine (UNM CMBM), our main focus is on both studying adverse health outcomes of
metal contaminants as well as on harnessing the chemical properties of metals for therapeutic and nutritional
purposes. Detailed knowledge of molecular interactions between metallic species and biomolecules can lead
to clinical and population-level interventions to improve public health. Towards this end, we have established a
new Integrative Molecular Analysis Core (IMAC) to provide members, and the UNM Health Sciences Center
campus, with cutting edge analytical chemistry instrumentation and techniques. is launching, still in its first
year, and seeing a surge of user interest and activity. In responding to needs of our research community,
several specific analytical applications require additional specialized instrumentation for high-accuracy small
molecule quantitation have been discussed. To provide the membership with a workhorse machine that can
handle targeted metabolomic and lipidomic assays, as well as examine DNA damage, oxidative biomarkers,
and metal-associated biomolecules, the Sciex 5500+ Triple QuadTM offers a superb cost-effective system to
meet our diverse quantitation needs. Featuring a high level of sensitivity, selectivity and linear dynamic range,
it allows for the most demanding quantitation analyses, such as challenges of severely interfered low-level
trace quantification that are commonly encountered during analysis of specific metabolites and biomarkers in
biological and environmental samples. Triple Quad LC-MS/MS systems deliver superior quantitative results in
a single injection workflow. By offering robust targeted quantitative analysis of known small molecules such as
metabolites, biomarkers and peptides of interests, it is a highly beneficial addition and expansion to our
Orbitrap LC-HRMS platform that is preferentially used for non-targeted protein analysis. This state-of-the-art
system is the first of its kind on our HSC campus. It will complement our current MS systems to provide new
and extended applications for our user base. Moreover, faster and more sensitive instrument will help with our
constant development of innovative bioanalytical methods to meet new research needs of our users.
Establishing this capacity at UNM will certainly meet the needs of a wider audience and expand the value of
our IMAC for the UNM HSC. Therefore, the 5500+ system will enhance our user access to and impact of the
resource, improve the productivity and efficiency in the laboratory, and help sustain the Core.

## Key facts

- **NIH application ID:** 10395875
- **Project number:** 3P20GM130422-02S2
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** Matthew J Campen
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $250,000
- **Award type:** 3
- **Project period:** 2020-07-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10395875

## Citation

> US National Institutes of Health, RePORTER application 10395875, New Mexico Center for Metals in Biology and Medicine - Equipment Supplement (3P20GM130422-02S2). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10395875. Licensed CC0.

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