# CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging > **NIH NIH R01** · GEORGIA STATE UNIVERSITY · 2021 · $353,742 ## Abstract CRCNS Research Proposal: Collaborative Research: Multimodal Dynamic Causal Learning for Neuroimaging A Project Description A.1 Introduction Many analyses of fMRI and other neuroimaging data aim to discover the underlying causal or commu- nication structures that generated that activity.1,2 An accurate characterization of these brain structures is important for understanding neural circuits, systems-level neuroscience, and the neural bases of var- ious cognitive psychological phenomena or mental diseases. Brain structures learned from neuroimag- ing data also provide a powerful diagnostic tool for predicting everything from the concepts currently in one’s mind3–5 to whether one suffers from different mental diseases.6–10 Given the importance of such brain connectivity networks, it is unsurprising that a wide variety of learning algorithms have been developed for different neuroimaging modalities. In particular, many of these methods aim to infer the underlying causal or connectivity networks from data (in contrast with model comparison methods such as dynamic causal modeling (DCM)11). These network discovery methods have achieved some notable successes,2,6,12–21 but have also largely failed to address two issues that can impede our ability to achieve improved understanding of the full, working brain. Our project will develop, validate, and apply methods that solve both of these challenges. First, existing brain connectivity inference methods can be roughly divided into two groups: static me- thods that do not actually treat the brain as a dynamic system (e.g., IMaGES22 and most of the ap- proaches tested by Smith et al.23); and dynamic methods that explicitly measure and model the dy- namics of the brain. Static methods obviously fail to use all of the available information. In contrast, dynamic methods use the full structure of the measurements, but essentially all such methods24–28 infer causal and connectivity structures at the timescale of the measurement modality, rather than at the brain’s causal timescale. However, the networks learned from data at the measurement and brain timescales can be quite different, even given solutions for all of the other statistical and measurement problems facing neuroimaging analysis.29 Moreover, the important facts about causal or connectivity structure are frequently about which brain regions communicate directly with which other brain re- gions, which requires a focus on the brain timescale, not the measurement modality timescale. It is thus scientifically critical that we have methods that can determine the causal connections that exist at the timescale of the underlying neural systems, not just those that are found at the timescale of our particular neuroimaging methods. Second, there are multiple neuroimaging measurement modalities, each with their own strengths and weaknesses. There are obvious and widely recognized advantages of multimodal information fusion: 1) access to multiple, richer datasets, l... ## Key facts - **NIH application ID:** 10396137 - **Project number:** 1R01MH129047-01 - **Recipient organization:** GEORGIA STATE UNIVERSITY - **Principal Investigator:** Sergey Plis - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $353,742 - **Award type:** 1 - **Project period:** 2021-08-05 → 2025-05-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10396137 ## Citation > US National Institutes of Health, RePORTER application 10396137, CRCNS: Multimodal Dynamic Causal Learning for Neuroimaging (1R01MH129047-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10396137. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*