# Functional Neuroanatomy Correlates of Worry in Older Adults

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $117,951

## Abstract

ABSTRACT
R01 MH108509 [FINA - Functional Neuroanatomy Correlates of Worry in Older Adults] was designed to
characterize the neurobiological pathways linking severe worry and emotion regulation processes in older
adults. We recently applied for a competing continuation 2 R01 MH108509-06 [The RAW Brain - The Effect
of Rumination, Anxiety and Worry on Aging and Dementia Risk]. Through the renewal we aim to identify the
pathways through which the rumination, anxiety and worry (RAW) phenotypes contribute to accelerated aging
and increased ADRD risk. The renewal aims to follow our currently well-characterized cohort of older adults,
and we plan to add 150 new older participants, similarly recruited on dimensional measures of rumination,
anxiety, and worry. We will repeat the assessments at two-year follow-up, giving us three time points for the
original cohort and two time-points for the new cohort. This will allow us to identify and monitor over time the
neural and biological pathways leading from RAW to brain and body aging. The total N proposed in RAW is
150 (FINA participants) + 150 new participants. In order to achieve the required design and power, the
renewal study relies on the FINA cohort of 150 older adults. The COVID pandemic mitigation efforts
have impacted the FINA grant tremendously, with significant delays and interruptions that limited the ability
to progress the current research study. The proposed supplement will aim to continue the recruitment for an
additional five months after the scheduled end of FINA (June 2021), which will allow us to reach the proposed
N. The funds are specifically aimed to recover salaries paid during shutdown. This is crucial for
both the successful analysis of data obtained during the current proposal (based on power calculations) but
also for the success of the renewed proposal. This proposal is responsive to NOT-MH-21-120 as: 1) it is
within the scope of the funded research; 2) FINA is in the last year of the award; 3) completion
of enrollment and follow-up are critical for both the success of the current project as well as the
proposed renewal.
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## Key facts

- **NIH application ID:** 10397731
- **Project number:** 3R01MH108509-05S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Carmen Andreescu
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $117,951
- **Award type:** 3
- **Project period:** 2016-09-20 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10397731

## Citation

> US National Institutes of Health, RePORTER application 10397731, Functional Neuroanatomy Correlates of Worry in Older Adults (3R01MH108509-05S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10397731. Licensed CC0.

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