# Development of reverse genetic systems and mouse model for SARS-CoV-2

> **NIH NIH R01** · UNIVERSITY OF TEXAS MED BR GALVESTON · 2021 · $197,500

## Abstract

ABSTRACT
The recent epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global
public health emergency. Rapid response to disease control and countermeasure development is a public health
priority. Reverse genetic systems and animal models are essential tools for studying viral replication,
pathogenesis, vaccine development, and antiviral discovery. The goals of this supplement project are to (i)
establish the reverse genetic systems and (ii) generate a mouse pathogenesis model for SARS-CoV-2.

## Key facts

- **NIH application ID:** 10398554
- **Project number:** 3R01AI134907-04S1
- **Recipient organization:** UNIVERSITY OF TEXAS MED BR GALVESTON
- **Principal Investigator:** Ricardo Rajsbaum
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $197,500
- **Award type:** 3
- **Project period:** 2020-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10398554

## Citation

> US National Institutes of Health, RePORTER application 10398554, Development of reverse genetic systems and mouse model for SARS-CoV-2 (3R01AI134907-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10398554. Licensed CC0.

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