# Dopamine system as reporter of HIV status and inflammation in Meth abusers

> **NIH NIH R01** · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · 2021 · $6,264

## Abstract

2021 NIDA Summer Research Internship Program
Systems Biology Approaches to identify Biological Processes associated with Genomic effects of
 Dopamine in HIV-infected Macrophages
Abstract
Macrophages, microglia and other immune cells that are targets of Human Immunodeficiency Virus infection
express receptors to dopamine, a neurotransmitter that is highly increased in the brain of stimulant drug
abusers, including Methamphetamine. Our lab has performed single cell CITE-seq experiments to determine
the role of dopamine in reactivating on maintaining the viral reservoir. The Summer Internship student will learn
to analyze large sets of data to produce integrated models of biomolecular networks. The student will be
virtually trained to administer systems biology strategies to big data and learn state-of-the-art methods for
predicting gene networks expressing synchronized behaviors. At the end of the internship, the student will
master a systems biology software, while exercising critical thinking, and produce results from our data set.

## Key facts

- **NIH application ID:** 10398692
- **Project number:** 3R01DA047822-03S1
- **Recipient organization:** SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE
- **Principal Investigator:** Maria Cecilia Garibaldi Marcondes
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $6,264
- **Award type:** 3
- **Project period:** 2021-02-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10398692

## Citation

> US National Institutes of Health, RePORTER application 10398692, Dopamine system as reporter of HIV status and inflammation in Meth abusers (3R01DA047822-03S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10398692. Licensed CC0.

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