# Preventing the Calcium Channel Blocker – Lower Extremity Edema – Loop Diuretic Prescribing Cascade in Older Adults

> **NIH NIH K08** · UNIVERSITY OF FLORIDA · 2022 · $159,970

## Abstract

PROJECT SUMMARY. Prescribing cascades (PCs), in which drug-induced adverse events (AEs) result in
additional treatment rather than deprescribing or dose reduction of the offending agent, are a central problem
in geriatric polypharmacy. Unlike other drug combinations that should be avoided, such as drug-drug
interactions, there is currently no process that alerts providers of PCs. To prevent or deprescribe PCs,
providers must evaluate complex medication regimens and multiple chronic conditions that may contribute to
drug-induced AEs. Appropriate design and implementation of clinical decision support (CDS) offers a
promising approach to enhance timely detection of PCs. In this work, I will use a research framework that
evaluates PCs and develops CDS tools for detection in clinical practice, using the example of a presumably
common and problematic PC: calcium channel blocker-associated lower extremity edema leading to the
prescribing of a loop diuretic (CCBLEELoop). My specific aims include (Aim 1) estimating the incidence
and evaluating which populations are at highest risk of CCBLEELoop PC, (Aim 2) quantifying
excess AEs, healthcare utilization, and costs associated with the CCBLEELoop PC, and (Aim 3)
developing and validating a CCBLEELoop PC algorithm for use in CDS to prospectively identify
individuals with the PC. This NIA K08 proposal will lay the foundation, both in training and research output,
for building an independent research program that combats polypharmacy in older adults, with particular focus
on minimizing unnecessary medication use. My extensive experience in geriatric clinical pharmacy and my role
as the Assistant Director of Pharmacy Services with University of Florida (UF) Health Physicians, the faculty
practice of UF Health, will ensure deep clinical context and relevance of this work. My initial exposure to
observational research methods and experience with Medicare data during my doctoral training will be
enhanced through this K award in three distinct areas relevant to the proposed work: (1)
pharmacoepidemiologic methods including the use of advanced longitudinal analyses to make causal
inferences on drug effects, (2) development and validation of CDS, and (3) implementation science. UF Health
is the largest fully-integrated academic health center in the Southeast and its excellent big data infrastructure
provides an ideal environment for achieving the proposed objectives and my long-term goals. Dr. Winterstein
will guide my training in pharmacoepidemiology and lead a multidisciplinary mentorship team composed of
experts in CDS development and implementation and economic evaluation of drug effects (Dr. Malone), aging
(Dr. Manini), biostatistics (Dr. Brumback), clinical management of hypertension (Dr. Pepine), clinical geriatrics
(Dr. Solberg), and alert development, evaluation, and implementation (Dr. Staley). The integrated mentored
research experience and training will allow me to compete for R01 funding focused o...

## Key facts

- **NIH application ID:** 10399417
- **Project number:** 5K08AG066854-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Scott Martin Vouri
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $159,970
- **Award type:** 5
- **Project period:** 2021-05-01 → 2022-10-20

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399417

## Citation

> US National Institutes of Health, RePORTER application 10399417, Preventing the Calcium Channel Blocker – Lower Extremity Edema – Loop Diuretic Prescribing Cascade in Older Adults (5K08AG066854-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10399417. Licensed CC0.

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