# EValuation Of Longitudinal outcomes in mild TBI Active-Duty Military and VEterans 10-Year

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2022 · $618,887

## Abstract

Project Summary/Abstract – PI: C. Mac Donald – EVOLVE-10 Study
The long-term clinical impact of war-time injuries remains incompletely described 1,2. Previous studies have
been based largely on self-report and screening tools 3-6 to define TBI, rather than direct clinical assessments in
cohorts identified at the time of injury and prospectively studied. As part of our prior efforts, we have
successfully completed prospective, observational, longitudinal studies enrolling active-duty US military directly
in the combat theatre in Afghanistan and following medical evacuation to Landstuhl, Germany at 0-7 days
(median 4) 17,18, 0-30 days (median 7-9) 19,20, and 0-90 days (median 14) 21-23 post-injury with evaluation at 1-
year 18-22 and 5-year 24,25 outcome to date. We remain the only study to date that has prospectively followed
active-duty US military from concussive brain injury directly in combat to long-term outcome with advanced MR
imaging and clinical evaluation. We will leverage this well characterized cohort in the current proposal to
investigate the long-term effects of mild-concussive traumatic brain injury (TBI) sustained during deployment in
US military personnel using advanced MR imaging and clinical outcome measures. We will relate these
findings to the prospectively acquired longitudinal imaging and clinical data from the acute, sub-acute, and
early chronic stages following combat concussion collected on these subjects as part of our prior efforts. We
hypothesize that combat concussion will differentially impact service members and that we will be able to
identify those at high risk of continued decline verses those with a trajectory of recovery by leveraging the
extensive early clinical and imaging data already collected in these very same patients linking it to the planned
10-year evaluation.
Specific Aim #1: Assess 10-year neurological, neuropsychological, and psychiatric clinical outcomes of
combat concussion in US military personnel leveraging previously acquired longitudinal data to identify
predictors of long-term clinical outcome.
Specific Aim #2: Examine 10-year advanced neuroimaging data in service members following combat
concussion in US military personnel leveraging previously acquired longitudinal data to identify predictors of
long-term imaging outcome.
Specific Aim #3: Explore functional trajectories over this first decade post-injury using latent growth models to
understand evolution or resolution of mental health symptoms, cognitive function, neurobehavioral symptoms
and neuroimaging measures following combat concussion.

## Key facts

- **NIH application ID:** 10399461
- **Project number:** 5R01NS091618-08
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Christine L MacDonald
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $618,887
- **Award type:** 5
- **Project period:** 2015-04-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399461

## Citation

> US National Institutes of Health, RePORTER application 10399461, EValuation Of Longitudinal outcomes in mild TBI Active-Duty Military and VEterans 10-Year (5R01NS091618-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10399461. Licensed CC0.

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