# Clinical Translational Core (Core B)

> **NIH NIH P01** · OHIO STATE UNIVERSITY · 2022 · $281,872

## Abstract

Clinical Translational Core (Core B): Abstract 
The acute respiratory distress syndrome (ARDS) affects 100-200K people in the U.S. yearly leading to death in 
approximately 35% of patients. Rather than the result of respiratory failure, mortality in ARDS patients typically 
results from multisystem organ failure or from hospital acquired infections. Recently, studies demonstrate that 
many patients with ARDS will experience a period of immune suppression or immunoparalysis following the early 
hyperinflammatory phase of the illness, the mechanistic and phenotypic basis of which is unclear. Therefore, 
this Program Project Proposal (P01) focuses on elucidating the molecular mechanisms underlying immune 
suppression in ARDS in order to identify novel pathways for therapeutic targeting. The Clinical Translational 
Core (Core B) is designed to optimize the translational exploration of the mechanisms identified in the P01 
Projects by providing: 1) de-identified human tissue and fluid samples (collected via a prospective IRB approved 
Registry and Biospecimen Repository) to project investigators for verification of human relevance of novel 
findings from the bench or from murine models, 2) a novel platform for translational investigation in the ex-vivo 
lung perfusion system whereby mechanistic pathways and potential therapeutic interventions demonstrating 
promise in murine models can be tested in a human system before administration to patients, and 3) expert 
statistical support and data management for Project Investigators. All four primary projects detailed within the 
proposal will utilize Core B to focus on discovery of novel immune suppressing pathways in key cell types 
involved in the pathogenesis of ARDS: type II alveolar pneumocytes (Projects 1 and 2) and inflammatory cells 
including the macrophages, myeloid cells, and host-protective lymphocytes (Projects 3 and 4). In providing these 
services, Core B integrates tightly and interacts closely with all projects comprising the P01 proposal.

## Key facts

- **NIH application ID:** 10399557
- **Project number:** 5P01HL114453-09
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** BRYAN J MCVERRY
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $281,872
- **Award type:** 5
- **Project period:** 2014-01-03 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399557

## Citation

> US National Institutes of Health, RePORTER application 10399557, Clinical Translational Core (Core B) (5P01HL114453-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10399557. Licensed CC0.

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