# RNAse functions in post-transcriptional gene regulation

> **NIH NIH R35** · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2022 · $475,015

## Abstract

PROJECT SUMMARY
All life forms must maintain a homeostatic gene expression program, which is achieved
at many different steps in gene expression, including by the degradation of specific
mRNAs and non-coding RNAs. Many evolutionarily conserved RNA processing
enzymes mediate these key post-transcriptional events, with important roles for endo
and exoribonucleases. A number of inherited diseases are caused by mutations in endo-
or exoribonuclease genes, further underscoring their importance for human health.
Eukaryotes use exonucleases for the degradation of most cellular mRNAs and for the 5'
and 3' end processing of many different ncRNAs. In addition, endonucleases target
specific mRNAs as an initiating step in mRNA degradation and other endonucleases
process ncRNAs. This proposal will focus on the functional characterization of
ribonucleases, especially functions in cytoplasmic mRNA degradation.

## Key facts

- **NIH application ID:** 10399566
- **Project number:** 5R35GM141710-02
- **Recipient organization:** UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- **Principal Investigator:** AMBRO VAN HOOF
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $475,015
- **Award type:** 5
- **Project period:** 2021-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399566

## Citation

> US National Institutes of Health, RePORTER application 10399566, RNAse functions in post-transcriptional gene regulation (5R35GM141710-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10399566. Licensed CC0.

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