# Acquisition of HyPix-6000HE Hybrid Photon Counting Detector and Universal Kappa 4-Axis Goniometer for the X-Ray diffraction system

> **NIH NIH P20** · UNIV OF ARKANSAS FOR MED SCIS · 2021 · $226,886

## Abstract

PROJECT SUMMARY/ ABSTRACT
The X-ray diffraction system, in the laboratory of Prof. Joshua Sakon (PI X-ray crystallography core), has
played and will continue to play a key role in the statewide research efforts in the structure determination of
biomolecules. His involvement in the Arkansas INBRE began in 2001 when the Arkansas BRIN was first
funded through a grant from the National Center for Research Resources. Dr. Sakon co-directs the
Biotechnology Core and in that role helps Arkansas INBRE network faculty and students access University of
Arkansas core facilities. This budget is for the acquisition of the HyPix-6000HE Hybrid Photon Counting
Detector and Universal Kappa 4-Axis Goniometer for the X-Ray diffraction system. The instrumentation will
enhance user access to new technology while replacing outdated equipment that is no longer serviceable by
the manufacturer. With the new installation, the deinstallation of Saturn-92 and AFC9, Beryllium window of left
port will also be required. The system, which was purchased in 2003, has provided an excellent return on
investment for 17 years. Eighty-one structures solved in the facility are validated and made accessible from the
Protein Data Bank (PDB). The facility provided 78.4% of three-dimensional structures deposited from our state
of Arkansas. During the period 2003−2021, the coordinates were frequently downloaded (1,685,267 times) and
examined using the website tools implemented by PDB (503,322 times) and led our state in impact (87.9% of
downloads and views). These structures are aiding in understanding protein architectures and designing new
molecules. The detector/goniometer portion of the system is in desperate need of upgrade. However, the old
detector is no longer supported by the manufacturer Replacing the existing detector/goniometer portion of the
system will extend the life of the X-ray diffraction system as well as increase the functionality and usability of
the system. The new generation X-ray detector will produce higher quality data and the software that now
comes with the detector/goniometer replacement will leverage advanced new algorithms developed in recent
years and will be capable of extracting more accurate information even with the same signal to noise ratio. The
investment will extend the capacity of the instrument from being a system dedicated to protein crystallography
to one that is capable of also generating high-quality analytics for small molecules. With the proposed upgrade
of the system, for less money than a new small molecule crystallography system, the facility can continue to
serve the needs of INBRE-, COBRE-, and as well as other NIH-supported investigators on this campus and
across the state.

## Key facts

- **NIH application ID:** 10399707
- **Project number:** 3P20GM103429-20S2
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **Principal Investigator:** Lawrence E Cornett
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $226,886
- **Award type:** 3
- **Project period:** 2001-09-30 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399707

## Citation

> US National Institutes of Health, RePORTER application 10399707, Acquisition of HyPix-6000HE Hybrid Photon Counting Detector and Universal Kappa 4-Axis Goniometer for the X-Ray diffraction system (3P20GM103429-20S2). Retrieved via AI Analytics 2026-06-10 from https://api.ai-analytics.org/grant/nih/10399707. Licensed CC0.

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