# COBRE-DIABETES

> **NIH NIH P20** · UNIVERSITY OF HAWAII AT MANOA · 2021 · $231,827

## Abstract

PROJECT SUMMARY/ABSTRACT
This application is for a supplement to support a Phase I Center of Biomedical Research Excellence (COBRE)
at the University of Hawaii (UH) on Diabetes (1P20GM113134-04) in response to funding opportunity NOT-
GM-21-029, “Administrative Supplements for Equipment Purchases for NIGMS-funded Center and Core
Facilities”. The COBRE-Diabetes has developed a Resource Core dedicated to supporting career development
for young investigators and to foster diabetes-related research in the state, which is acutely needed. It is
estimated that a third of the State’s population will be living with diabetes by the year 2050.
The COBRE-Diabetes Resource Core goal is to establish a new and easily accessible modern infrastructure to
support investigations in the mechanisms, diagnosis, prevention, and/or treatment of diabetes to address
health disparities in the minority populations in Hawaii. Our unique aim is to Maintain the growth and
enhance the sustainability of Resource Core. With this proposal, we will optimize our core capacity in order
to continue capacity improvement that has been successfully initiated in the first Phase of COBRE-Diabetes
funding. In order to accomplish this objective, we request funding for the acquisition of two new pieces of
equipment. We hope to replace an existing obsolete Xenogen Vivo Vision IVIS Lumina Imaging system with an
IVIS Lumina XRMS in vivo imaging system. This is equipment offers cutting edge in vivo fluorescence and
bioluminescence technology combined with low dose 2D X-ray allowing for non-invasive and precise metabolic
analyses. This will give us an expanded capacity with multiple animals to perform longitudinal studies. The
second equipment is an i-STAT clinical blood analyzer that operates with the advanced technology of single-
use i-STAT test cartridges offering a wide array of tests on a single platform, including rapid tests for
electrolytes, chemistries, blood gases, hematocrit and hemoglobin or the fast evaluation of metabolic status
and renal function. This system uses minimal blood volumes, which will not require animal (mouse) sacrifice.
Blood analyses are currently done using individual and dedicated kits that is laborious or contracting services
outside of the University. There are many projects ongoing in the DRC that can best be performed in Hawaii.
Our distance from US mainland requires that we develop a fundamental repertoire of Core services for
diabetes research with COBRE resources. The Dean of the Medical School has committed to provide
institutional support to cover the cost of operation for three years after the purchase of these equipment.

## Key facts

- **NIH application ID:** 10399857
- **Project number:** 3P20GM113134-05S2
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** MARIANA GERSCHENSON
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $231,827
- **Award type:** 3
- **Project period:** 2017-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399857

## Citation

> US National Institutes of Health, RePORTER application 10399857, COBRE-DIABETES (3P20GM113134-05S2). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10399857. Licensed CC0.

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