# Identification and Characterization of Nobel Genetic Mechanisms in Alcohol Use Disorder and Excessive Drinking

> **NIH NIH K99** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $111,326

## Abstract

Project summary
This supplement application requests a one-year extension of grant K99AA027835 with additional funds for
salary support for Dr. Amanda Barkley-Levenson. This supplement is needed due to the unforeseen and
extreme impacts on the funded project created by the COVID-19 pandemic and subsequent restrictions on
research activities. The aims of this project have not changed, but additional time is needed to complete the
planned work. No additional research funds are requested, and all experimental and animal costs will be paid
by the parent grant. During the proposed one-year extension, Dr. Barkley-Levenson will continue follow-up
evaluation of novel GWAS hits for problematic alcohol use using mutant mouse lines. She will complete
comprehensive behavioral phenotyping of Fut2 knockout mice by measuring ethanol effects on intracranial
self-stimulation, and withdrawal-associated escalation of drinking and negative affective changes in the chronic
intermittent ethanol exposure model (Aim 1). Dr. Barkley-Levenson will also complete behavioral phenotyping
of an initial cohort of AIL mice for preliminary GWAS analysis (Aim 2). These experiments were not possible in
the past year due to state and university restrictions on non-essential research and limits on in-person work but
are now able to proceed under current guidelines. No further delays are anticipated. During the extension
period, Dr. Barkley-Levenson will continue with career development activities including writing and publishing
papers, presenting at research conferences, mentoring undergraduate research assistants, applying for faculty
jobs, and working towards a timely transition to an independent position.

## Key facts

- **NIH application ID:** 10399924
- **Project number:** 3K99AA027835-02S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Amanda Malina Barkley-Levenson
- **Activity code:** K99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $111,326
- **Award type:** 3
- **Project period:** 2021-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399924

## Citation

> US National Institutes of Health, RePORTER application 10399924, Identification and Characterization of Nobel Genetic Mechanisms in Alcohol Use Disorder and Excessive Drinking (3K99AA027835-02S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10399924. Licensed CC0.

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