# Center for Cellular Metabolism Research in Oklahoma

> **NIH NIH P20** · OKLAHOMA MEDICAL RESEARCH FOUNDATION · 2021 · $230,540

## Abstract

PROJECT SUMMARY/ABSTRACT
OMRF operates three mouse barrier facilities with the only germ-free mouse facility (GFM) and patient-derived
xenograft core (PDX) in Oklahoma. The research programs of all five Research Project Leaders (RPLs) on this
new COBRE use mouse models, which make up approximately 15% of the daily mouse population of the
OMRF mouse facilities. As these investigators grow their research programs in the next five years, this
percentage is expected to increase to ~22%. In addition, the laboratories of the CMRO COBRE mentors also
utilize mouse models, and the mentors and RPLs combined currently constitute almost 60% of the census.
Reliable sterilization of mouse caging and ancillary equipment is essential for mouse barrier facilities,
especially those housing immunodeficient and germ-free mice. OMRF’s current sterilizer is 20 years old and is
failing. To address this, OMRF plans to replace the failing sterilizer and add a second sterilizer for future
expansion. This supplement requests partial support of the sterilizing equipment. OMRF will provide 50% of
the total cost for this equipment. The requested equipment is critical for reproducible results for research of the
CMRO COBRE RPLs and their mentors as well as animal health and well-being. Additionally, this equipment
will also benefit other COBRE and COBRE-eligible investigators from additional institutions in Oklahoma
(University of Oklahoma Health Sciences Center and Oklahoma State University), as the GFM and PDX
facilities are not found elsewhere in the state.

## Key facts

- **NIH application ID:** 10399960
- **Project number:** 3P20GM139763-01S1
- **Recipient organization:** OKLAHOMA MEDICAL RESEARCH FOUNDATION
- **Principal Investigator:** Lijun Xia
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $230,540
- **Award type:** 3
- **Project period:** 2021-05-01 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10399960

## Citation

> US National Institutes of Health, RePORTER application 10399960, Center for Cellular Metabolism Research in Oklahoma (3P20GM139763-01S1). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10399960. Licensed CC0.

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