# Shared Resource - Proteomics & Metabolomics Shared Resource

> **NIH NIH P30** · GEORGETOWN UNIVERSITY · 2022 · $112,713

## Abstract

ABSTRACT 
The molecular characterization of disease processes has become an indispensable component of current cancer 
research. The mission of the Proteomics & Metabolomics Shared Resource (PMSR) is to provide state-of-the- 
art chromatographic and mass spectrometric services for proteomics and metabolomics applications. The PMSR 
was established in 2006 for proteomics and expanded to metabolomics in 2008. Since the last review, PMSR’s 
activity and throughput have expanded dramatically; the PMSR provided services to 22 Georgetown Lombardi 
Comprehensive Cancer Center (LCCC) members in fiscal year (FY) 2017. Radoslav Goldman, PhD, oversaw 
proteomics operations through 03/2018, at which time he stepped down to focus on directing his newly formed 
Glycoscience Center. Byers replaced Goldman. Byers is the founder and a former director of the PMSR. 
Proteomics services include optimizing workflows and developing specialized services, which include identifying 
proteins and peptides and their modifications and quantification. Targeted liquid chromatography-mass 
spectrometry (LC-MS) experiments for specific proteins and their modifications facilitate the conduct of 
translational research applications. Cheema manages the metabolomics component. The metabolomics 
component includes comprehensive metabolomics and lipidomics profiling services from a variety of matrices, 
including tissue and cultured cells and biofluids, such as serum, plasma and urine. The PMSR has developed 
and optimized methods for protein and metabolite extraction from complex matrices such as cells, feces, ductal 
lavage fluid and cerebrospinal fluid. The proteomics and metabolomics services also include multiple reaction 
monitoring (MRM)-based targeted quantification, and metabolomics services further include high-resolution MS 
for small molecules. The Waters Corporation recognized the metabolomics component as a Center of Innovation. 
Waters has continually supported high-impact science, resulting in multiple extramurally funded grants with a 
metabolomics focus in at least one specific aim.

## Key facts

- **NIH application ID:** 10400653
- **Project number:** 5P30CA051008-29
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** Junfeng Ma
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $112,713
- **Award type:** 5
- **Project period:** 1997-08-15 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10400653

## Citation

> US National Institutes of Health, RePORTER application 10400653, Shared Resource - Proteomics & Metabolomics Shared Resource (5P30CA051008-29). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10400653. Licensed CC0.

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