Neural Circuit Mechanisms Mediating TMS and Oxytocin Effects on Social Cognition

NIH RePORTER · NIH · R37 · $753,755 · view on reporter.nih.gov ↗

Abstract

We are requesting an increase in the yearly direct costs to support the aims of the MERIT renewal. What we propose is a dramatic leap into the future of social neuroscience and lies at the bleeding edge of current technology. The proposed research is innovative, ambitious, and necessary for understanding how primate, and by extension human, brains enable appropriate social behavior in the real world. Our proposal advances understanding of how primate brains generate appropriate social behavior through a tightly-integrated, ambitious set of 4 specific aims combining simultaneous wireless neurophysiological recordings in multiple freely-moving monkeys interacting naturally in varied social contexts, semi-to-fully-automated quantification of social behavior using computer vision, pharmacological manipulations, and reversible perturbations of neural activity. To our knowledge, none of these experiments has ever been attempted in macaques. Our pilot data compellingly demonstrate that we can do it.

Key facts

NIH application ID
10401957
Project number
5R37MH109728-07
Recipient
UNIVERSITY OF PENNSYLVANIA
Principal Investigator
MICHAEL L PLATT
Activity code
R37
Funding institute
NIH
Fiscal year
2022
Award amount
$753,755
Award type
5
Project period
2021-05-05 → 2026-02-28