# Research Training in Hematology

> **NIH NIH T32** · UNIVERSITY OF WISCONSIN-MADISON · 2022 · $454,314

## Abstract

Our training program brings together twenty-two faculty members from eight Departments to focus on two
areas of broad importance for hematology and human disease: vascular biology and stem cell
biology/hematologic malignancy. The primary goal is to train M.D. and Ph.D. scientists in a multi-disciplinary
environment to do sustained, independent research in hematology. Two predoctoral positions are requested
that will be filled from an outstanding pool of Ph.D. and M.D.-Ph.D. students in the well-established graduate
programs at the University of Wisconsin (UW). Four postdoctoral positions are requested to train research
track candidates from participating clinical (Medicine, Pediatrics) and basic science (Biomedical Engineering,
Biomolecular Chemistry, Cell and Regenerative Medicine, Medical Microbiology & Immunology, Oncology, and
Pathology) departments. The highly interactive training faculty cluster into three interest groups: vascular
biology/inflammation; immune regulation, hematopoietic development/malignancy; and stem cell biology/bone
marrow transplantation. Expertise in vascular biology includes microfluidics, proteomics, cellular migration,
extracellular matrix biology, cellular mechanisms of inflammation, eosinophil biology, modeling of blood vessels
and cell migration, molecular aspects of hemostasis and thrombophilic states. Hematologic malignancy/stem
cell biology is led by a prominent group of stem cell investigators. Expertise includes embryonic (ES), induced
pluripotent (iPSC) and mesenchymal stem cell biology, epigenetic regulation of normal and abnormal
hematopoietic differentiation; intracellular signaling in hematopoiesis, leukemogenesis, and lymphocytes;
immunotherapy of myeloma, tumor immunology, preclinical models of allogeneic bone marrow transplant;
clinical trials and bone marrow imaging, and clinical applications of stem cells. Training opportunities span
basic and clinical investigation; including cutting-edge technologies in genomics, proteomics, metabolomics,
microfluidics, zebrafish and murine disease models, and stem cell transplantation. A strong emphasis is placed
on translational research and multidisciplinary training of clinical investigators. The UW Institute for Clinical and
Translational Research offers didactic and degree programs in clinical investigation, career development, and
mentoring expertise. Our trainees have an excellent record of establishing research careers. Fifteen
predoctoral appointees have now completed their Ph.D. degrees. Seven are in academic faculty or scientist
positions, three are industry scientists, two are completing advanced subspecialty clinical training, one is a
chemistry professor at a teaching college. Twenty-four post-doctoral trainees have completed their
appointments on the grant in the past fifteen years. These trainees include eleven assistant professors, two
associate professors, three academic scientists, two industry scientists, and two completing training. The larg...

## Key facts

- **NIH application ID:** 10402361
- **Project number:** 5T32HL007899-24
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** JOHN Patrick SHEEHAN
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $454,314
- **Award type:** 5
- **Project period:** 1998-07-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10402361

## Citation

> US National Institutes of Health, RePORTER application 10402361, Research Training in Hematology (5T32HL007899-24). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10402361. Licensed CC0.

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