# Insights into mitochondria-lysosome contact dynamics in neurodegeneration

> **NIH NIH R00** · NORTHWESTERN UNIVERSITY · 2021 · $31,065

## Abstract

PROJECT SUMMARY
Both mitochondria and lysosomes are critical for health and homeostasis, and dysfunction of both organelles
has been implicated in multiple neurodegenerative diseases. However, the crosstalk between these two
organelles in driving disease pathogenesis is still not well understood. Inter-organelle membrane contacts form
between different organelles and are critical sites for modulating organelle dynamics and function.
Mitochondria and lysosomes can form such inter-organelle contact sites, and their crosstalk at mitochondria-
lysosome contacts represents a key pathway for the bidirectional regulation of mitochondria and lysosomes.
Importantly, further studying the role of mitochondria-lysosome contacts may provide important insights into the
regulation of mitochondrial and lysosomal function, and their contribution to the etiology of different
neurological disorders. This research project will investigate the role of mitochondria-lysosome contact site
misregulation in specific neurodegenerative diseases using advanced time-lapse microscopy. Ultimately, the
proposed research will help uncover new mechanisms underlying disease pathogenesis at the intersection of
inter-organelle contact sites and neurodegeneration.

## Key facts

- **NIH application ID:** 10403821
- **Project number:** 3R00NS109252-03S1
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Yvette Wong
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $31,065
- **Award type:** 3
- **Project period:** 2021-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10403821

## Citation

> US National Institutes of Health, RePORTER application 10403821, Insights into mitochondria-lysosome contact dynamics in neurodegeneration (3R00NS109252-03S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10403821. Licensed CC0.

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