# UNC Center for AIDS Research Core C Clinical

> **NIH NIH P30** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $312,308

## Abstract

PROJECT SUMMARY/ABSTRACT – CLINICAL CORE (CORE C)
The UNC CFAR Clinical Core’s mission is to provide services and resources, centered on people living with and
at risk for HIV, to foster dynamic and innovative clinical and translational HIV research at UNC Chapel Hill, FHI
360 and RTI. The Core, led by Drs. Joseph Eron, Sonia Napravnik, and Claire Farel, is positioned to respond to
key emerging questions in HIV prevention, transmission, treatment, and pathogenesis in a region with high HIV
burden, morbidity, and mortality. Experienced leadership and close relationships with laboratory, clinical, and
public health research locally, nationally, and internationally create a diverse and robust resource. The Core
sustains the comprehensive and longstanding UNC CFAR HIV Clinical Cohort (UCHCC), with partnerships in
national and international HIV cohort collaborations, including CNICS, NA-ACCORD and IeDEA. The UCHCC
integrates real-time electronic medical records, with routine and standardized clinical record reviews, validated
and adjudicated clinical outcome ascertainments, and longitudinally collected biological specimens, augmented
by HIV sequence data, socio-behavioral surveys, patient reported outcomes, geospatial data, and state and
federally available data (e.g., HIV testing, mortality, US Census). The UCHCC supports research that capitalizes
on UNC’s fertile academic environment, enduring partnerships with state public health leadership, and
international clinical and research sites. The Core infrastructure includes a full time clinic-embedded screener to
recruit participants with and at risk for HIV from our well-characterized patient populations. Our study coordinator,
regulatory and research team, support protocol development and implementation, including prospective
collection of a broad range of samples, such as blood, CSF, gut and organ biopsies, and genital tract secretions
and tissue, enhancing clinical and translational research, and investigator productivity. We also provide web-
enabled tracking and data entry systems, database design and support for data management. Integration of the
Core within the larger UNC, RTI, and FHI 360 communities fosters opportunities to engage and mentor trainees
and early stage investigators, using the Core’s data, specimens and resources. The Core supports NIH networks,
including ACTG, HPTN, MACS/WIHS, and Ending the HIV Epidemic through recruitment efforts, data provision,
expertise and leadership in these groups. Our value-added, cost-effective and unique services and resources
support over 70 investigators annually with basic laboratory science, translational, clinical, epidemiology and
public health research, with over 40 OAR FRB investigators and over 500 papers supported in this funding cycle.
The Core is committed to innovation in improving and expanding services, to ongoing excellence and growth in
acquisition and use of specimens, extension and enrichment of data resources, enhancing outreach ...

## Key facts

- **NIH application ID:** 10404030
- **Project number:** 5P30AI050410-25
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Joseph J Eron
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $312,308
- **Award type:** 5
- **Project period:** 2001-08-20 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10404030

## Citation

> US National Institutes of Health, RePORTER application 10404030, UNC Center for AIDS Research Core C Clinical (5P30AI050410-25). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10404030. Licensed CC0.

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