# Negative regulation of inflammation during Klebsiella pneumoniae infection

> **NIH NIH R21** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $198,230

## Abstract

Project Summary
Infections with Klebsiella pneumoniae (KP) activate the IL-17 signaling pathway, which is crucial to constrain KP
dissemination and facilitate pathogen eradication. During this process, IL-17 is negatively regulated by RNA
binding proteins (RBP) in an effort to decrease collateral tissue damage in the host. One of these RBPs is
Regnase-1 (Reg1) which degrades IL-17- induced transcripts either through the coding region or 3'UTR. In this
proposal, we will investigate the role of Reg1 in the airway epithelium during KP pneumonia. We hypothesize
that Reg1 deficiency enhances the effect of pro-inflammatory transcripts in the airway epithelium which favors
immunity against KP. For that purpose, we will characterize a Reg1 conditional knockout in the airway epithelium
upon KP pneumonia as well as investigate Reg1 regulation at the epigenetic and post-transcriptional level.

## Key facts

- **NIH application ID:** 10404122
- **Project number:** 5R21AI153549-02
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Giraldina Trevejo-Nunez
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $198,230
- **Award type:** 5
- **Project period:** 2021-05-11 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10404122

## Citation

> US National Institutes of Health, RePORTER application 10404122, Negative regulation of inflammation during Klebsiella pneumoniae infection (5R21AI153549-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10404122. Licensed CC0.

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