PROJECT SUMMARY ADMINISTRATIVE CORE The Administrative (Admin) Core will provide the infrastructure to support all communication, coordination, oversight and management functions of the proposed Centers of Research Translation (CORT) P50. The Admin Core will be led by PD/PIs Virginia Pascual, PhD, and Duygu Ucar, PhD, with program management support from an experienced Program Administrator; and external advisory support from an External Advisory Committee (EAC). The Admin Core will contribute to program success by: 1) facilitating communication, organizing meetings, and fostering a strong collaborative environment among the PIs/Investigators; 2) providing oversight and monitoring of progress of the Projects and Core towards their specific milestones; 3) optimizing resource allocation and fiscal management; 4) seeking guidance from the EAC and NIH program officials, implementing their recommendations, and generating progress reports; 5) Arranging an annual EAC meeting and Lupus Symposium; 6) Oversee issues related to intellectual property and regulatory issues surrounding research using human subjects; 7) ensuring rigorous data and sample management and efficient data and resource sharing. These activities will be executed within five main areas of focus: (a) Leadership; (b) Management; (c) Communication; (d) Pilot & Feasibility Programs; and (e) Enrichment Programs. Through these activities, the Admin Core will provide the critical infrastructure necessary to ensure the proposed multi-site, and multi-project program achieves its component and collective goals, yields results of lasting and (inter)national impact, and positively benefits the patient population under study as well as the general public.