PROJECT SUMMARY/ABSTRACT Bioinformatics Core The purpose of this Core is to provide bioinformatic analysis of transcriptomic data. Our Core will provide the essential data analysis service to render this data accessible and interpretable to the members of this consortium. The directors and staff of this Core have extensive experience in the analysis of genomic data, as well as familiarity with the underlying biology of the associated projects. Specifically, we will process bulk, single cell and spatial transcriptomic data using existing pipelines. Moreover, we have developed tools to interpret transcriptomic profiles in terms of cell type and inflammatory signatures. We also have expertise in the use of data integration tools to combine our transcriptomic data with genetic and lipidomic data. Finally, we will provide tools for data visualization, such as an R Shiny server for viewing individual genes in two dimensional projections of single cell transcriptomes. The Core we are proposing here will allow all the groups within this CORT to receive analyzed data that can be directly interpreted by researchers without extensive computational expertise. This functionality should render genomics research far more accessible to all members of this CORT.