PROJECT SUMMARY (See instructions): RTI International proposes to continue to serve as the data coordinating center (DCC) for the NICHD Pelvic Floor Disorders Network (PFDN) in support of its mission to improve the care of women with pelvic floor disorders (PFDs) by conducting well-designed multicenter observational studies and clinical trials to inform diagnosis, prevention, and treatment. We will build on our work as the DCC in the current PFDN cycle to provide PFDN with statistical leadership, statistical data analysis and reporting, and operational support through data management and logistical services. Specifically, we will (1) continue monitoring ongoing Network protocols; (2) provide data management, including preparation of public data files; (3) prepare reports, including safety reports for the Data and Safety Monitoring Board; (4) collaborate in the analysis of data and publication of study results; (5) coordinate collection and transport of biological specimens; and (6) provide all other support, including management of capitation payments to clinical sites, and logistical coordination of meetings and communications necessary to run an efficient and productive Network.