# Caging Solution for Macaques Assigned to AIDS Research projects Requiring Antiretroviral Therapy

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $98,550

## Abstract

PROJECT SUMMARY
The U42 SPF4 grant at the Oregon National Primate Research Center (ONPRC) helps to support an active
and highly productive HIV/AIDS research program. Significant increases in grant funding and the need for
larger group sizes have strained the Center's resources, particularly space and caging. Therefore, additional
caging is being requested to support this research by providing optimal long-term housing that better
addresses the welfare of the animal subjects that are assigned to projects requiring daily antiretroviral therapy
(ART).
The ONPRC has multiple caging types, which can broadly be split into two categories: standard cages 32
inches in height with 4.5 sq. ft. of floor space and large cages 36 inches in height with 6- 6.5 sq. ft. of floor
space. Larger, taller cages are better suited for promoting positive well-being, and are necessary for social
housing adult males over 10kg. ART studies tend to be of long duration resulting in animals often exceeding 10
kg in body weight and therefore requiring the larger size caging. In addition, the cages being requested have
been optimized for ease of administration of ART. There is an enlarged opening in the front that allows for the
technician to more easily and safely inject the animal, and the squeeze-back mechanism has been refined,
compared to older caging to provide better restraint during this procedure. These cages have also been
designed to better facilitate the attachment of procedure cages that are used for blood collection. At the
ONPRC there are currently 115 macaques assigned to AIDS related research requiring ART. Based on current
projections, HIV/AIDS NHP assignments requiring ART could increase to 250 within the next year.
The ONPRC is in significant need of new, updated caging for our NHP research areas. This new caging will
support HIV/AIDS research by providing right-sized housing that is optimized for macaques requiring daily
antiretroviral therapy. Nine one-over-one Socialization Racks (18 cages total) will be purchased to be placed in
infectious disease research appropriate animal holding rooms.

## Key facts

- **NIH application ID:** 10404868
- **Project number:** 3U42OD010426-19S1
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Gregory Brion Timmel
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $98,550
- **Award type:** 3
- **Project period:** 2021-06-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10404868

## Citation

> US National Institutes of Health, RePORTER application 10404868, Caging Solution for Macaques Assigned to AIDS Research projects Requiring Antiretroviral Therapy (3U42OD010426-19S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10404868. Licensed CC0.

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