# Field Core (Core B)

> **NIH NIH P01** · HEBREW REHABILITATION CENTER FOR AGED · 2022 · $385,782

## Abstract

CORE B ABSTRACT
The Program Project (P01) entitled “Delirium, Dementia and the Vulnerable Brain: An Integrative
Approach” seeks to define the complex relationship of delirium, dementia, and brain vulnerability through a
series of five, interrelated projects, each of which examines a unique aspect of vulnerability. The Field Core will
support all of the projects and has the following Specific Aims:
Aim 1: To perform assessments on the original Successful Aging after Elective Surgery (SAGES I) cohort free
of dementia at baseline (N=560), ensuring the highest possible participant retention and completeness of study
variables. Activities include: 1) For the entire SAGES I cohort, completing two waves of long-term follow-up
interviews: the first wave (years 1-3) will ensure a minimum of 5 years of follow-up, and the second wave
(years 3-5) will ensure a minimum of 8 years of follow-up; 2) Inviting 128 SAGES I participants, probability
sampled based on their index admission delirium status and frequency matched by age and baseline cognitive
status, to return to the hospital for a detailed evaluation, including cerebrospinal fluid (CSF) collection via
lumbar puncture (LP) for Alzheimer's Disease (AD) and inflammatory biomarker measurement, phlebotomy for
plasma AD and inflammatory marker measurement, magnetic resonance imaging (MRI) studies, and
transcranial magnetic stimulation (TMS)-electroencephalography (EEG) studies.
Aim 2: To accrue a new cohort, called SAGES II, of 400 patients undergoing total hip or knee replacements
under spinal anesthesia at two academic medical centers, Beth Israel Deaconess Medical Center (BIDMC) and
Brigham and Women's Hospital (BWH), and to follow this cohort for 18 months with extended follow-up to 36
months. Activities related to the SAGES II cohort include: 1) identifying, approaching, and enrolling eligible
patients with a goal of achieving the highest possible participation; 2) performing baseline assessments prior to
surgery, in-hospital assessments for delirium daily throughout the index hospitalization, and follow-up
assessments at 1, 2, 6, 12, 18, months after surgery, with extended follow-up at 24 and 36 months; 3)
providing specialized support for each of the component projects by collecting CSF and blood samples for AD
and inflammatory biomarker measurement, and referring patients for MRI, TMS, and EEG studies.
Aim 3: To hire, train, and monitor the activities of all field staff, ensuring coordination of all aspects of the
SAGES I and II cohort studies including study participant safety, and high quality data collection.
Through execution of these Aims, the Field Core will play an essential role in all aspects of the Program
Project, which will define the complex relationship of delirium, dementia, and brain vulnerability. The Field Core
has been highly successful in achieving all of its Aims in the first funding cycle. In the renewal, we will
implement the same principles and procedures, employ many of the sa...

## Key facts

- **NIH application ID:** 10405115
- **Project number:** 5P01AG031720-10
- **Recipient organization:** HEBREW REHABILITATION CENTER FOR AGED
- **Principal Investigator:** EDWARD R MARCANTONIO
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $385,782
- **Award type:** 5
- **Project period:** 2018-09-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10405115

## Citation

> US National Institutes of Health, RePORTER application 10405115, Field Core (Core B) (5P01AG031720-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10405115. Licensed CC0.

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