# Induction of lupus-related autoantibodies by TNF inhibitors

> **NIH NIH U19** · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · 2021 · $684,079

## Abstract

Abstract
This proposal seeks to test two hypotheses regarding the Multisystem Inflammatory Syndrome
(MIS-C) recently identified in children and young adults infected with SARS-CoV-2. We
hypothesize that there is a spectrum of disease from severe acute disease to MIS-C. Severe
Cov acute disease is associated with low interferon production, poor control of virus and a
germinal center derived antibody response to the virus leading to long term immunity while MIS-
C is associated with high interferon, efficient control of virus, but an extrafollicular derived
antibody response with poor long term immunity. We will test this hypothesis through a genetic
analysis, analysis of serum cytokines and analysis of anti-viral antibodies. We also hypothesize
that plasma metabolic profile of subjects with MIS-C will predict short term cardiac dysfunction
and long term cardiac damage.

## Key facts

- **NIH application ID:** 10405223
- **Project number:** 3U19AI144306-03S1
- **Recipient organization:** FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Anne Davidson
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $684,079
- **Award type:** 3
- **Project period:** 2021-05-19 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10405223

## Citation

> US National Institutes of Health, RePORTER application 10405223, Induction of lupus-related autoantibodies by TNF inhibitors (3U19AI144306-03S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10405223. Licensed CC0.

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