# CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules

> **NIH NIH K23** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2021 · $65,016

## Abstract

PROJECT SUMMARY/ABSTRACT
The original description of the K23 project will not change – as re-iterated below:
Research: The National Lung Screening Trial (NLST) demonstrated a 20% reduction in mortality with the use
of annual CT screening but with significant morbidity due to procedures performed for evaluation of the 94% of
nodules that were not cancerous. The goal of this proposal is to improve the specificity for distinguishing which
of these “indeterminate” nodules is lung cancer by using quantitative features associated with emphysema
available from a single CT scan. Our preliminary data indicate that moderate centrilobular emphysema (MCE),
and its associated vascular features, provide a niche for the growth of nascent lung. An innovative approach of
this proposal is to use features of MCE in the sphere of lung around a nodule to improve specificity for detecting
cancer. However, increasing specificity results in decreasing sensitivity. In the case of lung cancer screening
more “missed” cancers may increase lung cancer deaths. To understand the effect of decreasing sensitivity on
mortality we will use the novel UVM Lung Cancer Model, which accurately recapitulates lung cancer death and
CT screening rates, to identify an optimal set of biomarkers for identifying cancer among the many screen
detected nodules.
Candidate: Dr. Kinsey's clinical practice is in Interventional Pulmonary, a specialty that focuses on dealing with
the problem of indeterminate nodules. He has applied his MPH epidemiology and biostatistical training, coupled
with experience in quantitative CT imaging, to begin to address the problem of indeterminate nodules in the
COPD Gene data set and as the Principal Investigator of the UVM Molecular, Epigenetic, and Radiologic
Biomarkers for Thoracic Cancers (MEROPTIC)study. However, he needs further training in the process of
developing CT features as imaging biomarkers and in computer modeling, which will allow him to understand
the effect of deployment of these biomarkers on lung cancer mortality. To address these critical gaps in
knowledge his primary mentor, Dr. Jason Bates, has designed a program of didactic training and supervised
research that will propel Dr. Kinsey to an independent investigator in the field of lung cancer diagnosis.
Environment: Dr. Kinsey's primary mentor, Dr. Bates, is internationally recognized for his work in pulmonary
physiology and computer modeling and has a proven track record of training investigators and physician
scientists. The co-mentor, Dr. George Washko, is an expert in quantitative imaging analysis and has an
established mentoring relationship with Dr. Kinsey. A scientific advisory committee with established expertise in
radiology, biostatistics, lung cancer, and biomarker development complements this outstanding mentoring team.
Dr. Kinsey is further supported by a network of individuals and resources, under the auspices of the Vermont
Lung Center and University of Vermont Cancer Center, that...

## Key facts

- **NIH application ID:** 10405873
- **Project number:** 3K23HL133476-05S1
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Charles Matthew Kinsey
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $65,016
- **Award type:** 3
- **Project period:** 2021-08-01 → 2022-03-09

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10405873

## Citation

> US National Institutes of Health, RePORTER application 10405873, CT Characteristics of Emphysema for Evaluation of Pulmonary Nodules (3K23HL133476-05S1). Retrieved via AI Analytics 2026-06-23 from https://api.ai-analytics.org/grant/nih/10405873. Licensed CC0.

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