# Enhancements to the SPF Colony to Increase Production and Efficiency in Management

> **NIH NIH U42** · EMORY UNIVERSITY · 2021 · $408,440

## Abstract

Project Summary/ Abstract
The AIDS research portfolio at Yerkes National Primate Research Center (YNPRC) has continued to expand
as demonstrated by a peak growth of approximately $6.5 million dollars (30% increase) in nonhuman primate
(NHP) AIDS research grant funding over the past eight years. This growth in grant funding is accompanied by
a high demand for Indian-origin specific pathogen free (SPF) rhesus macaques as the animal model for this
research. YNPRC has continued to maintain a colony of SPF rhesus macaques under the parent grant (U42
OD011023) to provide these animals for HIV/AIDS research. This supplement application titled “Enhancements
to the SPF Colony to Increase Production and Efficiency in Management” requests support for (1) the addition
of novel “introduction enclosures” to select U42 supported compounds in the SPF colony that will ultimately
increase production in the breeding colony and (2) the acquisition of a mobile procedure room and new capture
tunnels that improve the efficiency of annual animal examinations and SPF testing of the colony.
The goals of this supplement proposal will facilitate enhancements to the management and husbandry core in
the parent U42 grant. The goals of the husbandry and management core are to leverage the resources
provided by the U42 to maximize production of Indian-origin rhesus monkeys and facilitate allocation of these
animals for NIH-funded HIV/AIDS research. This supplemental application will contribute to these goals with
the following two specific aims: (1) to build additional introduction enclosures to improve the success of the
introduction of multiple breeder males to female groups, thereby improving adult sex ratios and animal
production and (2) to acquire a veterinary trailer and restraint capture tunnels to improve the efficiency of
annual health surveys performed on the SPF colony at the Field Station
Achieving these aims will help increase production and enhance management of the Yerkes U42 supported
SPF breeding colony to ensure the program is sustainable, providing the necessary animals to support the
HIV/AIDS research program using Indian-origin rhesus monkeys. The availability of this critical resource to
scientists performing preclinical studies using the rhesus monkey model will have a positive, significant impact
on the development of treatments to prevent or cure infection from HIV in people.

## Key facts

- **NIH application ID:** 10405992
- **Project number:** 3U42OD011023-18S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Joyce Kimberly Cohen
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $408,440
- **Award type:** 3
- **Project period:** 2002-09-03 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10405992

## Citation

> US National Institutes of Health, RePORTER application 10405992, Enhancements to the SPF Colony to Increase Production and Efficiency in Management (3U42OD011023-18S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10405992. Licensed CC0.

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