# Selective Control of Synaptically-Connected Circuit Elements by Interluminescence - Diversity Supplement: E. CRESPO

> **NIH NIH R01** · CENTRAL MICHIGAN UNIVERSITY · 2021 · $113,187

## Abstract

PROJECT SUMMARY/ABSTRACT
The Diversity Supplement candidate will be trained in all aspects of validating Interluminescence in vivo with
acute extracellular recordings and computational sophisticated electrophysiological analysis. The experimental
approach will allow the candidate to assess Interluminescence with a well-defined experimental model to dissect
cortical dynamics.
The training experience the candidate will gain are critical for his understanding, designing, and interpretation of
state-of-the-art neural data. The training plan will complement his prior extensive training in molecular and
cellular neuroscience. Following this experience in applying chemogenetic and optogenetic tools in vivo, the
candidate will have an exceedingly strong background for meeting his career goals. His training will have ranged
from hands-on experience developing novel probes at the level of the engineered protein, to their intended use
in controlling neural activity and behavior. Therefore, this training in in vivo electrophysiology will not only
significantly contribute to the parent grant but will specifically provide him the experience required to dissect
neocortical dynamics and come “full circle” in the tool development pipeline.
The proposed training outlined in the application is ideal given the candidate’s productive track record. An
established team training strategy between the two mentors will foster the candidate’s ability to independently
investigate the role of synaptically-connected circuits.
The proposed supplement activities will increase the parent award’s overall impact within the original scope of
award while at the same time advancing the training and career development of the candidate.

## Key facts

- **NIH application ID:** 10406018
- **Project number:** 3R01NS120832-01S1
- **Recipient organization:** CENTRAL MICHIGAN UNIVERSITY
- **Principal Investigator:** UTE H HOCHGESCHWENDER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $113,187
- **Award type:** 3
- **Project period:** 2021-04-15 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10406018

## Citation

> US National Institutes of Health, RePORTER application 10406018, Selective Control of Synaptically-Connected Circuit Elements by Interluminescence - Diversity Supplement: E. CRESPO (3R01NS120832-01S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10406018. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*