# Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF Biomarkers

> **NIH NIH U01** · EMORY UNIVERSITY · 2021 · $295,155

## Abstract

The goal of the parent AMP-AD project is to identify proteomic networks from cortical tissue and identify
protein co-expression modules that are strongly associated with diagnosis, cognition and neuropathology.
These studies hinge on accurate neuropathologic diagnosis and staging of the brain tissue. These
assessments typically involve semi-quantitative evaluation of tissues and there is a need for robust, reliable,
and scalable deeper phenotyping to provide a firmer foundation for precision medicine approaches. We have
developed the Digital Slide Archive (DSA) platform at Emory, which has been funded through a U24 and U01
grants from the NCI/NIH and has primarily been optimized for Cancer related image analysis workflows. In this
project, we propose to deploy and customize a web-based instance of our open source management and
visualization platform, the Digital Slide Archive (DSA). Ultimately, we will enable collaborative team science
and adapt the existing DSA platform for a neuropathologist’s workflow. This will directly enhance the value of
our proteomic work by allowing us to better annotate our brain/proteomic samples.
 In this proposal, we propose enhancing the user interface of the DSA to better accommodate a
neuropathologist’s workflow for reviewing brain tissue, and develop an easily installable Neuropath plugin for
the DSA. We will also benchmark and optimize our analysis suite (HistomicsTK) on NP slide sides on local
and cloud-based computational resources, and prepare tutorials demonstrating how our tools can be used for
ADRD related image analysis tasks. These aims paired with the complementary and synergistic expertise of
our informatics, pathology, and engineering will aid in development of robust, scalable, reliable, and sharable
platforms to provide a foundation for innovative transformative science addressing a critical unmet need in
neurodegenerative disease research.

## Key facts

- **NIH application ID:** 10406764
- **Project number:** 3U01AG061357-04S1
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** David Andrew Gutman
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $295,155
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10406764

## Citation

> US National Institutes of Health, RePORTER application 10406764, Supplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF Biomarkers (3U01AG061357-04S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10406764. Licensed CC0.

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