# Program 3: Cancer BiologyProgram (CBP)

> **NIH NIH P30** · UNIVERSITY OF ARIZONA · 2021 · $42,168

## Abstract

Project Summary / Abstract: Cancer Biology Program (CBP) 
The goal of the Cancer Biology Program (CBP) is to identify etiologic mechanisms underlying cancer 
development and progression. As the main basic science of cancer platform for the University of Arizona 
Cancer Center, the Cancer Biology Program seeks to advance fundamental knowledge of the complex 
biological networks that are deranged in cancer and to characterize interactions between these complex 
biological networks and the environment that promote carcinogenesis and tumor progression. Translation of 
current findings and development of novel approaches to cancer prevention and treatment is facilitated through 
inter-programmatic collaborations and Cancer Center support. The program is organized into three major 
themes, including Genomic Instability and Epigenetic Control of Gene Expression, Signaling Networks in 
Carcinogenesis and Tumor Progression, and Invasion and Metastasis, with four aims: (i) to investigate 
mechanisms of cancer initiation and progression and to characterize cellular mechanisms that control cancer 
metastasis, (ii) to identify networks and regulatory pathways as potential markers or targets in prevention and 
treatment, (iii) to promote intra- and inter-programmatic collaborations to enhance translational research along 
the continuum from pre-clinical mouse models and human tissue correlates to clinical trials, and (iv) to foster 
research directions of particular relevance to individuals in Arizona and the Southwest. The Cancer Biology 
Program achieves these aims through establishment of working groups, conferences and seminars, and 
development of inter-disciplinary scientific teams; faculty recruitment, membership development and 
mentoring, and the use of developmental funds to spur targeted research; and, guidance and support of the 
shared resources. The CBP has 49 Members representing 21 different departments at the University of 
Arizona. CBP Members have published 390 cancer-relevant manuscripts, of which 30% were intra- 
programmatic and 36% were inter-programmatic. As of September 1, 2015, the CBP Program secured $11.8M 
total annual grant dollars with $2.5M from the NCI and $8.3M in other peer-reviewed funding. The CBP has 
regional impact through its members' basic research into the carcinogenic mechanisms of arsenicals that are 
pervasive environmental carcinogens in the Southwest. Finally, the Program is invested in using modern, high 
throughput genomic platforms to develop, enhance, and implement precision medicine. The expanding 
representation of Hispanic Americans in the State's population impels increased research into cancer health 
disparities in this population.

## Key facts

- **NIH application ID:** 10407097
- **Project number:** 3P30CA023074-40S6
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Cynthia K Miranti
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $42,168
- **Award type:** 3
- **Project period:** 1997-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407097

## Citation

> US National Institutes of Health, RePORTER application 10407097, Program 3: Cancer BiologyProgram (CBP) (3P30CA023074-40S6). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10407097. Licensed CC0.

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