# Protocol Review and Monitoring System

> **NIH NIH P30** · UNIVERSITY OF ARIZONA · 2021 · $64,335

## Abstract

Project Summary / Abstract: Protocol Review and Monitoring System (PRMS) 
The conduct of cancer clinical trials is central to the scientific mission of the University of Arizona Cancer 
Center (UACC). The development and implementation of a broad portfolio of cancer trials requires an 
extensive institutional commitment of scientific, operational, and patient resources; thus, oversight of the 
scientific merit and progress of the trial portfolio is paramount in ensuring that trial outcomes help shape the 
future of cancer prevention and treatment. The internal oversight of the scientific aspects of all cancer trials 
and the monitoring of the progress of cancer trials research is managed by the UACC Protocol Review and 
Monitoring System (PRMS). The Scientific Review Committee (SRC) serves as the principal functional 
component of the PRMS; it is the chartered, multidisciplinary body charged with the ultimate review of the 
scientific merit, prioritization, and progress of all cancer trials proposed by UACC Principal Investigators, with 
the exception of those trials that have undergone external peer-review through NIH and its funding agencies. 
The SRC membership is composed of a broad spectrum of specialists in cancer treatment, cancer prevention, 
therapeutic development, and basic and population science that mirrors the breadth of the UACC's clinical trial 
portfolio. Cancer trials are risk-stratified for determination of need for full Committee versus administrative 
expedited review. A systematic process is in place for the monitoring of accrual to trials and of trial scientific 
progress. The SRC has the authority to terminate trials that have not met pre-specified accrual targets or that 
are not meeting their scientific objectives. The PRMS performance metrics are generated by the clinical 
research system OnCore® and provide the basis for PRMS quality improvement initiatives.

## Key facts

- **NIH application ID:** 10407102
- **Project number:** 3P30CA023074-40S6
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Linda Lee Garland
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $64,335
- **Award type:** 3
- **Project period:** 1997-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407102

## Citation

> US National Institutes of Health, RePORTER application 10407102, Protocol Review and Monitoring System (3P30CA023074-40S6). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10407102. Licensed CC0.

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