# Investigation of sirtuin 1 expression in mice model of Alzheimer's disease  over age

> **NIH NIH R03** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $323,760

## Abstract

Project Summary
Sirtuin 1 has been implicated in multiple functions is thought as one of the candidate molecules for promoting
healthy aging, because of its neuroprotective roles against several age-related pathologies, and several studies
done in animals showed an association between sirtuin 1 and lifespan elongation. Sirtuin 1 has been shown to
impact several brain disorders such as neurodegenerative disorders, such as Alzheimer’s disease. Therefore, it
is important to have a tool for non-invasive measurement of sirtuin 1 expression and function in vivo, and PET
imaging would be an ideal tool.
Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes
in animals or in man until we developed the first PET imaging probe for sirtuin 1 recently. The development of
techniques for visualizing sirtuin 1 in vivo represents a key step in understanding both the normal function and
pathophysiology of sirtuin 1 in brain. Moreover, these techniques these techniques will accelerate the
discovery/development of small molecule therapeutics that selectively interacts with sirtuin 1. The project is
aimed to measure the expression of sirtuin 1 in brain of Alzheimer’s Disease animal model and wild-type mice
over age, using our novel PET imaging probe, [11C]CWL-1, prior to first-in-human imaging.

## Key facts

- **NIH application ID:** 10407173
- **Project number:** 1R03AG076389-01
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Changning Wang
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $323,760
- **Award type:** 1
- **Project period:** 2022-06-01 → 2024-05-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407173

## Citation

> US National Institutes of Health, RePORTER application 10407173, Investigation of sirtuin 1 expression in mice model of Alzheimer's disease  over age (1R03AG076389-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10407173. Licensed CC0.

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