# The University of Southern California and Buck Institute Nathan Shock Center

> **NIH NIH P30** · BUCK INSTITUTE FOR RESEARCH ON AGING · 2021 · $273,500

## Abstract

ABSTRACT OF SUPPLEMENT
Our Nathan Shock Center (NSC) of Excellence (P30 AG068345) provides access to geroscience technology,
research training, and research support for geroscientists across the United States. NSCs focus on the basic
biology of aging and thus use a variety of methodologies and technologies to advance our understanding of
geroscience. Users of our NSC study a variety of biological variables at the molecular, cell, tissue, organ, and
organismal levels. In addition to the requests from the geroscience community to use the vast resources of our
Geroscience Technology Core (GTC) and the expertise of our NSC faculty at USC, we are often asked if we can
couple these powerful studies with microscopy and visual measurements. Currently, high resolution and
multiplex imaging is not a service that is available at our NSC and represents an unmet need of the community
of geroscience researchers that utilize our NSC cores. In order to advance the availability of microscopy
technology for the geroscience research projects performed at USC, we propose the purchase of the Zeiss LSM
980 confocal microscope - currently the fastest super-resolution system that enables the acquisition of a wide
range of molecular, cellular, tissue, and organismal details of live samples. These measures are essential to
our ability to fully understand the underlying basis of aging and age-related diseases across all hierarchical
levels. Our administrative supplement will establish a powerful new tool in the arsenal of technologies in the
Geroscience Technology Core (GTC). These new technologies represent an unexpected opportunity for USC
to advance the imaging research capacity, available to all geroscience users of our NSC services at the Leonard
Davis School of Gerontology at USC. As such, our administrative supplement will greatly impact geroscience
nation-wide.

## Key facts

- **NIH application ID:** 10407740
- **Project number:** 3P30AG068345-02S1
- **Recipient organization:** BUCK INSTITUTE FOR RESEARCH ON AGING
- **Principal Investigator:** Sean P CURRAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $273,500
- **Award type:** 3
- **Project period:** 2020-09-15 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407740

## Citation

> US National Institutes of Health, RePORTER application 10407740, The University of Southern California and Buck Institute Nathan Shock Center (3P30AG068345-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10407740. Licensed CC0.

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