CENTER OVERVIEW: PROJECT SUMMARY/ABSTRACT The Stanford Diabetes Research Center (SDRC) embodies the culmination of a strategic plan by the Stanford University School of Medicine to create a premier program founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes research. The SDRC mission is to foster innovation, new knowledge, and training in diabetes-related research, leading to improved diagnosis, treatment, and ultimately, prevention and cure of diabetes and its complications. Renewal of this P30 application will leverage diabetes research at Stanford University by providing crucial resources dedicated to supporting investigations and enrichment activities focused on diabetes. Stanford has a strong tradition of academic excellence, innovation, and clinical care, united in a true University on a single campus that fosters interactions between scientists and clinicians from different disciplines. Stanford is in the heart of Silicon Valley, an epicenter of innovation and calculated risk-taking, whose companies partner with SDRC faculty in unique and growing collaborations to advance diabetes research and care. Stanford neighbors two Universities of California (UC) at Berkeley, and at Davis, both elite research centers with a growing diabetes research base unconnected to a NIDDK DRC. The SDRC is comprised of 124 members from 3 Schools at Stanford, and from multiple Schools at UC Berkeley and UC Davis. SDRC members at Stanford currently have $65,044,250 in annual direct costs for diabetes-related research. SDRC members are organized by affinity groups focused on (i) Islet & Pancreas Biology, (ii) Metabolism & Signaling, (iii) Immunology, Transplantation & Stem Cell Biology, and (iv) Bioengineering & Behavioral Sciences. The SDRC consists of: (1) Administrative Component that coordinates scientific, organizational, enrichment, training and outreach activities, (2) Biomedical Research Component that recruits and selects members, and supervises 4 Research Cores that facilitate and enhance their research, and (3) a successful SDRC Pilot and Feasibility (P&F) Award Program that promotes the diabetes research of early stage investigators, and established scientists new to diabetes research. We propose to expand this Program to include a Regional P&F Program that supports research at UC Davis and Berkeley. NIH support for the SDRC is amplified by (1) Stanford’s sustained commitment to provide space and significant financial resources, (2) a comprehensive array of institutional research cores, which allow NIDDK funds to support specialized SDRC research cores devoted to diabetes research, (3) collaborative efforts with other Stanford research centers, and (4) SDRC member leadership of high-profile national diabetes research efforts. Since P30 funding began in 2017, the SDRC has evolved, including growth of its investigator base, intensified focus on translational research, and modification of...