# Biomarker Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $218,207

## Abstract

BIOMARKER CORE SUMMARY/ ABSTRACT
 In this renewal application, we will add a Biomarkers Core to the existing infrastructure of the UCSD ADRC.
Since its inception in 1984, the UCSD ADRC has committed to developing a robust collection of biofluids and
neuroimages from the cohort which have been integrated into the Neuropathology and Clinical Cores,
respectively. With the needs of our program and research increasing and the instructions of this RFA, we are
establishing a dedicated Biomarkers Core to manage, analyze and share ADRC biofluids and images and their
related datasets.
 We anticipate that our fluid and imaging resources will greatly aid in identifying new mechanisms underlying
dementia. We propose 5 Aims of the Biomarkers Core: 1) Biofluid and image collection using established
SOPs and best practice guidelines; 2) Perform standardized biomarker analyses on CSF and imaging,
including Aβ and tau levels, APOE and TREM2 genotyping, hippocampal, cortical and ventricular volumes and
analysis of Aβ and tau PET scans; 3) Develop a state of the art biobank and imaging dataset to support
research nationally and internationally; 4) Develop and maintain a state of the art biofluid and imaging
repository to provide the ADRC projects and other investigators with well characterized including early AD and
MCI cases; 5) Foster the utilization of the ADRC Biofluids and images for new research and inter-center
collaborations.
 With the ADRC Outreach, Recruitment and Education (ORE) Core organize meetings to encourage the use
of the biomarkers core. We will continue to provide DNA to local and national investigators and for multi-center
initiatives such as NCRAD and the Genome-Wide Analysis Studies organized by NIA.

## Key facts

- **NIH application ID:** 10407984
- **Project number:** 5P30AG062429-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Robert Rissman
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $218,207
- **Award type:** 5
- **Project period:** 2019-05-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10407984

## Citation

> US National Institutes of Health, RePORTER application 10407984, Biomarker Core (5P30AG062429-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10407984. Licensed CC0.

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